一、简介

吕志创，女，1978年7月出生，博士，副研究员，广西玉林人。2001年和2005年分别于广西大学获学士和硕士学位，2009年1月于中国农业科学院研究生院获博士学位。2009年1月至今于中国农业科学院植物保护研究所生物入侵研究室工作，主要从事入侵昆虫快速适应环境的分子和表观遗传调控机制，入侵昆虫生长发育和繁殖调控关键基因及调控途径，以及研发以纳米材料为载体的新型RNAi防控害虫的研究。先后主持国家自然科学基金青年基金项1项、面上项目2项、国家重点研发计划课题和子课题各1项，参加国家973重点研究计划、农业公益性行业科研专项等多项课题的研究工作。发表论文近50篇篇，其中在 Entomologia Generalis、International Journal of Molecular Sciences、Journal of Experimental Biology、Comparative Biochemistry and Physiology Part D、Molecular Ecology Note、Insect Molecular Biology、Pest Management Science等国际期刊发表SCI论文26篇；已获授权专利27项，包括23项国家发明专利和4项实用新型专利；获软著著作权1项；参编专著3部。

联系方式：

E-mail：lvzhichuang@caas.cn，grasslzc@163.com

Tel：010-82109572, 13717960266

二、主持项目/课题：

1、国家自然科学基金面上项目：烟粉虱MED隐种响应温度胁迫的染色质重塑调控机制（32072494）（2021.01-2024.12, 69.6万）

2、国家自然科学基金面上项目：BtTRP和Hsps在烟粉虱Q隐种耐温性差异中的参与机制（31672088）（2017.01-2020.12, 78万）

3、国家青年科学基金“B型烟粉虱对温度适应性的遗传和分子机制”（31100269), 2012-2014, 22万）

4、国家重点研发计划“重要入侵生物表型可塑性变异及快速生态适应”（2016YFC1200603），2016.7-2018.12, 207万

5、国家重点研发计划子课题“绿色高效防控关键技术与产品研发”（2021YFD1400204-01，202105-202512，231万）

三、主要论文（^#共同第一作者，*通讯作者）

Ji SX, Wu QW, Bi SY, Wang XD, Zhang GF, Wan FH, Lü ZC* and Liu WX. Chromatin-remodelling ATPases ISWI and BRM are essential for reproduction in the destructive pest Tuta absoluta. International Journal of Molecular Sciences. 2022, 23, 3267. https://doi.org/10.3390/ijms23063267.

Ji SX, Wang XD, Lin ZK, Wan FH, Lü ZC* and Liu WX. Characterization of chromatin remodeling genes involved in thermal tolerance of biologically invasive Bemisia tabaci. Frontiers in Physiology. 2022. 13: 865172. doi: 10.3389/fphys.2022.865172.

Ji SX, Bi SY, Wang XD, Wu Q, Tang YH, Zhang GF, Wan FH, Lü ZC* and Liu WX. First report on CRISPR/Cas9-based genome editing in the destructive invasive pest Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae). Frontiers in Genetics. 2022, 13: 865622.doi: 10.3389/fgene.2022.865622.

Wang XD, Lin ZK, Ji SX, Bi SY, Liu WX, Zhang GF, Wan FH, and Lü ZC*. Molecular characterization of TRPA subfamily genes and function intemperature preference in Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae). International Journal of Molecular Sciences. 2021, 22, 7157. https://doi.org/10.3390/ijms22137157.

Shen XN, Ji SX, Liu WX, Guo JY, Lü ZC* and Wan FH*. Molecular characteristics of three cold resistance genes and their roles in temperature stress response in Bemisia tabaci (Hemiptera: Aleyrodidae) two cryptic species. Entomologia Generalis, 2021, 41(4): 317-328. DOI: 10.1127/entomologia/2021/0954.

Ji SX, Shen XN, Liang L, Wang XD, Liu WX, Wan FH, and Lü ZC*. Molecular characteristics and temperature tolerance function of Transient Receptor Potential in the native Bemisia tabaci AsiaII3 cryptic species. Journal of Integrative Agriculture. 2020, 19(11): 2746–2757.

Ji SX, Wang XD, Shen XN, LL, Liu WX, Wan FH, and Lü ZC*. Using RNA interference to reveal the function of 2 chromatin remodeling factor ISWI in temperature tolerance in Bemisia tabaci Middle East Asia Minor 1 Cryptic Species. Insects, 2020, 11, 113.

Dai TM, Wang YS Liu WX, Lü ZC*, and Wan FH. Thermal Discrimination and Transgenerational Temperature Response in Bemisia tabaci Mediterranean (Hemiptera: Aleyrodidae): Putative Involvement of the Thermo-Sensitive Receptor BtTRPA. Environmental Entomology, 47(1), 2018, 204-209.

Dai TM, Lü ZC, Wang YS, Liu WX, Hong XY , Wan FH. Molecular characterizations of DNA methyltransferase 3 and its roles in temperature tolerance in the whitefly, Bemisia tabaci Mediterranean. Insect Molecular Biology. 2018, 27(1): 123-132.

Lü ZC, Wang LH, Zhang GF, Guo JY, Wan FH*. 2014. Evaluation of endogenous reference genes of Bactrocera minax (Tetradacus) for gene expression profiling under various experimental conditions. Florida Entomologist, 97(2): 597-604.

Lü ZC, Wang YM,  Zhu SG, Yu H, Guo JY, Wan FH*. 2014. Trade-offs between survival, longevity and reproduction and considerable genetic variation in survival tolerance in the Mediterranean whitefly, Bemisia tabaci after temperature stress. Journal of Insect Science, 2014, 14(124):1-14.

Lü ZC, Gao QL, Yu H, Guo JY, Wan FH*. 2014. Increased survival and prolonged longevity mainly contribute to the temperature-adaptive evolutionary strategy in invasive Bemisia tabaci Middle East Asia Minor 1. Journal of Insect Science, 2014, 14(143): 1-5.

Lü ZC, Wang LH, Zhang GF, Wan FH, Guo JY, Yu H, Wang JB. 2014. Three heat shock protein genes from Bactrocera minax (Tetradacus): gene cloning, characterization and relation with diapause. Neotropical Entomology, 43: 362-372.

Lü ZC, Sun HB, Wan FH*, Guo JY, Zhang GF. 2013. High variation in single nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) in the highly invasive Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) Middle East-Asia Minor 1 (MEAM1). Neotropical Entomology, 42: 521-526.

Lü ZC, Wan FH*. 2011. Using double-stranded RNA to explore the role of heat shock protein genes in heat tolerance in Bemisia tabaci (Gennadius). Journal of Experimental Biology, 214: 764-769.

Lü ZC, Wan FH*. Differential gene expression in whitefly (Bemisia tabaci) B-biotype females and males under heat-shock condition. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics. 2008. 3: 257-262.

冀顺霞, 王晓迪, 申晓娜, 刘万学, 万方浩,吕志创*. 染色质重塑调控生物温度适应性的研究进展. 生物安全学报, 2021, 30(2): 79-88.

王晓迪, 冀顺霞, 申晓娜, 刘万学, 万方浩, 张桂芬*，吕志创*. 碱基编辑技术及其在昆虫中的应用和展望. 中国生物防治学报, 2021, 2021, 37(3): 609-619. doi.org/10.16409/j.cnki.2095-039x.2021.03.003.

王晓迪, 冀顺霞, 申晓娜, 刘万学, 万方浩, 吕志创*. 温度胁迫下昆虫表观遗传机制的研究进展. 中国生物防治学报，2021, 37(03): 598-608, doi: 10.16409/j.cnki.2095-039x.2021.01.010.

王晓迪, 冀顺霞, 申晓娜, 刘万学, 万方浩, 张桂芬*，吕志创*. 纳米载导RNAi技术在害虫防治中的研究和应用. 中国生物防治学报, 2021, 37(5): 1298-1312. doi: 10.16409/j.cnki.2095-039x.2021.01.020.