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李.方.方

      

李.方.方,中国农业科学院植物保护研究所研究员,博士生导师。2009年获南京农业大学植物保护专业学士学位,2014年获浙江大学植物病理学专业博士学位。2014-2015年在浙江大学从事博士后研究,2015-2018年在加拿大农业与农业食品部,伦敦研究与发展中心先后从事博士后、助理研究员工作。2018年引进至中国农业科学院植物保护研究所,植物病虫害生物学国家重点实验室工作,在植物与病毒互作实验室开展具体工作。

实验室主要围绕农业生产中的重要作物病毒病害开展研究工作,通过解析植物病毒致病与寄主抗病的机理,研发植物病毒病害的绿色防控技术。涉及的寄主途径包含DNA修饰、RNA修饰与降解、蛋白质翻译后修饰与降解等。通过系统分析植物与病毒在DNA、RNA和蛋白质水平上的分子竞赛,开发高效的抗病毒基因编辑体系,创制抗病毒新种质,筛选防控病毒病的绿色农药,为病毒病的绿色防控提供了重要的理论支持和技术保障。发表论文/著作50余篇,以通讯作者/第一作者身份在Molecular Plant(2篇)、Nature Communications (2篇)、Trends in Microbiology(3篇)、Science China Life Sciences (4篇)、New Phytologist(4篇)、PLoS Pathogens(4篇)、Plant Physiology(3篇)等刊物发表论文、专著39篇(累计影响因子超过320),影响因子大于10的高水平论文15篇。研究成果获‘中国农业科学院科学技术成果奖’1项(第一完成人)、‘中国农业科学院植物保护研究所2021年重大科技成果奖’1项(第二完成人)、获国家发明专利授权7项(第一完成人)。先后主持国家重点研发青年科学家项目、国家高层次人才项目、国家自然科学基金面上项目等项目8项,参与国家科技部973计划课题、国家自然科学基金重大/重点项目、加拿大农业部与加拿大自然科学与工程研究委员会资助的多项课题。李.方.方于2018年入选中国农业科学院植物保护研究所“青年英才计划引进工程”;2019年入选“国家海外高层次引进人才”;2020年入选“中国农业科学院巾帼建功标兵”;2021年入选农业农村部“农业科研杰出人才”培养计划;2022年获“第18届中国青年女科学家奖”、“第21届全国青年岗位能手标兵”;兼任Molecular Plant-Microbe Interactions、Frontiers in Microbiology期刊的Associate Editor,Frontiers in Plant Science、Frontiers in Genome Editing、Virology等期刊的Review Editor等职务。


联系电话:13641100481

邮箱: ffli@ippcaas.cn 或elva1988@163.com

代表性论文(#共同第一作者,*共同通讯作者)

[1] Linhao Ge, Buwei Cao, Rui Qiao, Hongguang Cui, Shaofang Li, Hongying Shan, Pan Gong, Mingzhen Zhang, Hao Li, Aiming Wang, Xueping Zhou*, Fangfang Li*. SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants. Molecular Plant (2023) (IF="21.949)

[2] Buwei Cao, Linhao Ge, Mingzhen Zhang, Fangfang Li*, Xueping Zhou*. Geminiviral C2 proteins inhibit active autophagy to facilitate virus infection by impairing the interaction of ATG7 and ATG8. Journal of Integrative Plant Biology (2023) (IF="9.106)

[3] Hao He, Linhao Ge, Zhaolei Li, Xueping Zhou*, Fangfang Li*. Pepino mosaic virus antagonizes plant m6A modification by promoting the autophagic degradation of the m6A writer HAKAI. aBiotech (2023)

[4] Pan Gong, Siwen Zhao, Hui Liu, Zhaoyang Chang, Fangfang Li*, Xueping Zhou*. Tomato yellow leaf curl virus V3 protein traffics along microfilaments to plasmodesmata to promote virus cell-to-cell movement. Science China-Life Sciences (2022) . 27(9):792-805. (IF="10.372)

[5] Yushuang Guo, Meng-ao Jia, Shaofang Li*, Fangfang Li*. Geminiviruses boost active DNA demethylation for counter-defense.  Trends in Microbiology  (2022)  (IF="18.230)

[6] Pan Gong, Huang Tan, Siwen Zhao, Hao Li, Hui Liu, Yu Ma, Xi Zhang, Junjie Rong, Xing Fu, Rosa Lozano-Durán*, Fangfang Li*, Xueping Zhou*. Geminiviruses encode additional small proteins with specific subcellular localizations and virulence function.  Nature Communications  (2021), 12(1):4278. (IF="17.694)

[7] Mingzhen Zhang, Pan Gong, Linhao Ge, Zhaoyang Chang, Xiaofei Cheng, Xueping Zhou, Aiming Wang, Fangfang Li*. Nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity.  New Phytologist (2021), 232(3):1382-1398. (IF="10.323)

[8] Fangfang Li*, Mingzhen Zhang, Changwei Zhang, Xueping Zhou. Nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in Solanaceous plants.  New Phytologist (2020), 225(4): 1746-1761. (IF="10.323)

[9] Fangfang Li#, Changwei Zhang#, Ziwei Tang, Lingrui Zhang, Zhaoji Dai, Shanwu Lyu, Yinzi Li, Xilin Hou, Mark Bernards, Aiming Wang*. A plant RNA virus activates selective autophagy in a UPR-dependent manner to promote virus infection.  New Phytologist (2020), 228(2):622-639.  (IF="10.323)

[10] Fangfang Li, Aiming Wang*. RNA-targeted antiviral immunity: more than just RNA silencing.  Trends in Microbiology  (2019), 27(9):792-805. (IF="18.230)

[11] Fangfang Li, Wende Liu, Xueping Zhou*. Pivoting plant immunity from theory to the field.  Science China-Life Sciences (2019), 62(11):1539-1542. (IF="10.372)

[12] Fangfang Li, Changwei Zhang, Yinzi Li, Guanwei Wu, Xilin Hou, Xueping Zhou, Aiming Wang*. Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase.  Nature Communications  (2018), 9(1):1268. (IF="17.694)

[13] Fangfang Li, Xiuling Yang, David M Bisaro, Xueping Zhou*. The βC1 protein of geminivirus-betasatellite complexes: A target and repressor of host defenses.  Molecular Plant  (2018), 11:1424-1426. (IF="21.949)

[14] Fangfang Li#, Xiongbiao Xu#, Changjun Huang, Zhouhang Gu, Linge Cao, Tao Hu, Ming Ding, Zhenghe Li, Xueping Zhou*. The AC5 protein encoded by mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing‐based antiviral defenses.  New Phytologist  (2015), 208(2):555-569.  (IF="10.476)

[15] Sang‐Ho Park#, Fangfang Li#, Justin Renaud, Wentao Shen, Yinzi Li, Lihua Guo, Hongguang Cui, Mark Sumarah, Aiming Wang*. NbEXPA1, an α-expansin, is plasmodesmata-specific and a novel host factor for potyviral infection.  The Plant Journal (2017), 2(5): 846-861.  (IF=8.972)

[16] Fangfang Li#, Weidi Wang#, Nan Zhao, Bingguang Xiao, Peijian Cao, Xingfu Wu, Chuyu Ye, Enhui Shen, Jie Qiu, Qian-Hao Zhu, Jiahua Xie, Xueping Zhou*, Longjiang Fan*. Regulation of nicotine biosynthesis by an endogenous target mimicry of microRNA in tobacco.  Plant Physiology (2015), 169(2): 1062-1071. (IF="8.972)

[17] Tingting Zhou, Mingzhen Zhang, Pan Gong, Fangfang Li*, Xueping Zhou*. Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection.  PLoS Pathogens  (2021), 17(9): e1009956. (IF="7.455)

[18] Fangfang Li, Aiming Wang*. RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors.  PLoS pathogens (2018), 14.8: e1007228. (IF="7.455)

[19] Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou*. A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in  Nicotiana benthamiana .  PLoS Pathogens  (2017), 13(2): e1006213. (IF="7.455)

[20] Fangfang Li, Changjun Huang, Zhenghe Li, Xueping Zhou*. Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression.  PLoS Pathogens (2014), 10: e1003921.  (IF="7.455)


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